2018 World Premiere: a life-changing therapy for SCI patients

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Neurogel en marche – 2017, the year of tangible achievements for the Neurogel project

    Dear members, donors; and all those involved in fighting for a worldwide cure for paralysis,

    First of all, we would like to offer our best wishes for the year 2017


    We are entering a new phase of our associative project.

    After funding numerous research and studies, we are now prepared to start clinical trials on humans.
    As you know, we gradually moved away from Neurogel because even more promising results were obtained with the activated fat produced by Professor Gorio's team in Milan.
 

A first clinical trial for the dermis (= skin lesions) is planned for summer 2017.

The dermis trial is a necessary phase prior to the implant of activated fat into the spinal cord.
This trial does not require any specific authorization because the transfer of adipose tissue is a current practice in plastic surgery.
The properties of activated fat enable the effective treatment of numerous skin lesions (sclerodermis; burns, bed sores, etc… )
Read more on the blog
Following this skin trial, we will launch our first spinal cord trial.
We are still waiting for the publications on activated fat in a lesion in mice, within the framework of Parkinson’s disease.
    Professor Gorio will make a presentation through a video as soon as his publications are published. His publications and the excellent results obtained will allow us to advance our clinical project for a spinal cord trial.
    The 10 patient trial, includes the required post-op intensive physiotherapy, will amount to about 3 million Euros.
    The success of the test on the dermis will help obtain funds from investors who are eager to see results.
    We will provide you with regular updates regarding any future developments and progress of the various phases.
    We are looking for a new neurosurgeon for our clinical trial on the spinal cord.
    We had the honor of counting prestigious neurosurgeon, Dr. Antonio Reis of Lisbon Portugal as a member of our scientific council. He was actually nominated man of the year in his country in 2006.
    Unfortunately, Dr. Reis has passed away and we are currently looking for a neurosurgeon capable of carrying out his protocol to implant activated fat. We have narrowed our choice down to three neurosurgeons.
    We are also grieved by the passing away of our secretary, Stéphanie Mauberret, companion of Jean-Luc Gay, our president, and mother of their little girl Anaïs. We pay tribute to her for the unrelentless and incredible work she performed for so many years to advance our project.
    Jean-Luc Gay is very affected by his loss, but we look forward to his return which is essential to our project, in view of his expertise in clinical trial regulations.
    Professor Gorio underwent hip replacement surgery in November 2016 and should be able to get back to his laboratory by the end of January. This explains the slight delay in publications.
 

    Does activated fat affect the quality of Neurogel?

    The answer is no, because Neurogel is a hydrogel that has amply shown that it was suitable for supporting the growth of a new tissue within a lesion.
    In this sense, Neurogel was the right choice: it provided a three-dimensional, biocompatible and bioadhesive growth bridge.
    However, it has its limitations and requires combination with stem cells and / or other growth factors for better functional recovery.
    Many similar studies have been carried out, such as Professor Eva Sykova’s in 2010 , combining mesenchenchymal stem cells with a similar type of hydrogel. Today, numerous studies use a growth matrix combined with stem cells or other factors. It seems Neurogel has set a trend.
The results obtained with Neurogel are not yet those expected for reasons that we explained in part in Jean-Luc Gay’s March 2016 newsletter.


    This led to the following question, “Why not combine Neurogel with activated fat or specific stem cells from activated fat?”

    Professor Gorio's preclinical tests have shown that his activated grease is bio-adhesive, like Neurogel.
    It also turns out
    that the structure of the activated fat is three-dimensional;
    unlike artificial biomaterials such as Neurogel, activated fat from adipose tissue is not fragile;
    the manipulation is practical and the implantation adjusts very easily to all forms of spinal cord lesions.

    Activated fat is an autologous implant, that is, it comes from the patient and it has not been genetically or enzymatically modified. It is a natural implant, without ethical constraint and without risk.
    An evaluation by histology and microscopy showed the implant of the activated fat remained in the lesion site for more than 3 weeks.
    Activated fat acts as an implant with stem cells, and is  capable of surviving for a long time within an injured site, differentiating into neural cells and possessing extremely high levels of immunosuppressive, anti-inflammatory factors and numerous cell growth factors .
    In short, each of us is endowed with a natural form of Neurogel, much more powerful than an engineered one.
    So here we are at last, on the last stretch of the road to clinical trials, and this is why, today, more than ever we need your mobilization.
    I want to take the opportunity to thank our members, families, associations and friends for the fabulous work they have freely provided, informing people about our project and raising funds.
    We must now finalize our project:  we can do it with your help and with the help of people of good will.
    Till next time then, with even more news on activated fat and our project.
    Pierre Rondio
    Acting President